RRP8 Antikörper (N-Term)

Produktnummer ABIN2791072

Dieser Anti-RRP8 Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von RRP8 in WB. Geeignet für Human, Ratte, Rind (Kuh), Pferd, Kaninchen, Meerschweinchen, Hund und Saccharomyces cerevisiae.

Kurzübersicht für RRP8 Antikörper (N-Term) (ABIN2791072)

Target: RRP8 (Ribosomal RNA Processing 8 (RRP8))

Reaktivität: Human, Ratte, Rind (Kuh), Pferd, Kaninchen, Meerschweinchen, Hund, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RRP8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-RRP8 Antikörper

Bindungsspezifität: N-Term

Sequenz: GPPCSDSEEE VERKKKCHKQ ALVGSDSAED EKRKRKCQKH APINSAQHLD

Homologie: Cow: 80%, Dog: 85%, Guinea Pig: 91%, Horse: 85%, Human: 100%, Rabbit: 100%, Rat: 93%, Yeast: 90%

Produktmerkmale: This is a rabbit polyclonal antibody against RRP8. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human RRP8

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 456 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu RRP8

Target: RRP8 (Ribosomal RNA Processing 8 (RRP8))

Andere Bezeichnung: RRP8

Hintergrund: RRP8 is an essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
Alias Symbols: KIAA0409
Protein Interaction Partner: RNF2, SIRT7, SIRT1, SUV39H1, USP39,
Protein Size: 456

Molekulargewicht: 50 kDa

Gen-ID: 23378

NCBI Accession: NM_015324, NP_056139

UniProt: O43159